terça-feira, 13 de janeiro de 2015

Autism as a disorder of biological and behavioral rhythms: Towards new therapeutic perspectives

Front. Pediatr. | doi: 10.3389/fped.2015.00001

Sylvie Tordjman1*Katherine Davlantis8Nicolas Georgieff2Mario Speranza3Jean Xavier4, Michel Botbol5, Cecile Oriol1, Julie Vernay-Leconte6David Cohen4, Solenn Kermarrec1, Olvier Bonnot7 and Geraldine Dawson8
  • 1Pole Hospitalo-Universitaire de Psychiatrie de l''Enfant et de l'Adolescent, Universite de Rennes 1, France
  • 2Department of Child and Adolescent Psychiatry, Centre Hospitalier Le Vinatier, France
  • 3Department of Child and Adolescent Psychiatry, Centre Hospitalier de Versailles, France
  • 4Child and Adolescent Psychiatry, Groupe Hospitalier Pitié-Salpétrière, France
  • 5Child and Adolescent Psychiatry, UBO, France
  • 6Department of Adult Psychiatry, Centre Hospitalier Guillaume Régnier, France
  • 7Adolescent and Adult Psychiatry, CHU de Nantes, France
  • 8Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, USA
http://journal.frontiersin.org/Journal/10.3389/fped.2015.00001/abstract

There is a growing interest in the role of biological and behavioral rhythms in typical and atypical development. Recent studies in cognitive and developmental psychology have highlighted the importance of rhythmicity and synchrony of motor, emotional and relational rhythms in early development of social communication. The synchronization of rhythms allows tuning and adaptation to the external environment. The role of melatonin in the ontogenetic establishment of circadian rhythms and the synchronization of peripheral oscillators suggests that this hormone might be also involved in the synchrony of motor, emotional and relational rhythms. Autism provides a challenging model of physiological and behavioral rhythm disturbances and their possible effects on the development of social communication impairments and repetitive behaviors or interests. This article situates autism as a disorder of biological and behavioral rhythms and reviews the recent literature on the role of rhythmicity and synchrony of rhythms in child development. Finally, the hypothesis is developed that an integrated approach focusing on biological, motor, emotional and relational rhythms may open interesting therapeutic perspectives for children with autism. More specifically, promising avenues are discussed for potential therapeutic benefits in autism spectrum disorder of melatonin combined with developmental behavioral interventions that emphasize synchrony such as the Early Start Denver Model (ESDM).
Keywords: Autism Spectrum Disorder, Biological rhythms, Melatonin, synchronization of rhythms, motor and relational rhythms, Therapeutics, Early Start Denver Model (ESDM)
Citation: Tordjman S, Davlantis K, Georgieff N, Speranza M, Xavier J, Botbol M, Oriol C, Vernay-Leconte J, Cohen D, Kermarrec S, Bonnot O and Dawson G (2015). Autism as a disorder of biological and behavioral rhythms: Towards new therapeutic perspectives. Front. Pediatr. 3:1. doi: 10.3389/fped.2015.00001
Received: 20 Aug 2014; Accepted: 05 Jan 2015. 
Edited by:
Roberto Canitano, University Hospital of Siena, Italy
Reviewed by:
Rajshekhar Bipeta, Associate Professor of Psychiatry, Gandhi Medical College and Hospital, India 
Felipe Ortuño, Clínica Universidad de Navarra, Spain 
Roberto Canitano, University Hospital of Siena, Italy  
Copyright: © 2015 Tordjman, Davlantis, Georgieff, Speranza, Xavier, Botbol, Oriol, Vernay-Leconte, Cohen, Kermarrec, Bonnot and Dawson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Prof. Sylvie Tordjman, Pole Hospitalo-Universitaire de Psychiatrie de l''Enfant et de l'Adolescent, Universite de Rennes 1, Rennes, France, s.tordjman@yahoo.fr

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